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Oxamflatin Improves Developmental Competence of Porcine Somatic Cell Nuclear Transfer Embryos

1 Oct 2012

Abstract excerpt

Abstract Aberrant epigenetic nuclear reprogramming of somatic nuclei is a major cause of low success in cloning. It has been demonstrated that treatment of histone deacetylase inhibitors (HDACi) enhances developmental potential of somatic cell nuclear transfer (SCNT) embryos by alteration of epigenetic status. The aim of the present study was to investigate the effect of oxamflatin, a novel HDACi, on the...

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PMID: 23013534
DOI: 10.1089/cell.2012.0007

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