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Oxamflatin Treatment Enhances Cloned Porcine Embryo Development and Nuclear Reprogramming <sup/>

30 Dec 2014

Abstract excerpt

Faulty epigenetic reprogramming of somatic nuclei is thought to be the main reason for low cloning efficiency by somatic cell nuclear transfer (SCNT). Histone deacetylase inhibitors (HDACi), such as Scriptaid, improve developmental competence of SCNT embryos in several species. Another HDACi, Oxamflatin, is about 100 times more potent than Scriptaid in the ability to inhibit nuclear-specific HDACs. The present...

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PMID: 25548976
DOI: 10.1089/cell.2014.0075

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Oxamflatin Treatment Enhances Cloned Porcine Embryo Development and Nuclear Reprogramming <sup/>PMID 25548976Read ↗

Oxamflatin Improves Developmental Competence of Porcine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Effects of Histone Deacetylase Inhibitor Oxamflatin on <i>In Vitro</i> Porcine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

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