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Effects of Histone Deacetylase Inhibitor Oxamflatin on <i>In Vitro</i> Porcine Somatic Cell Nuclear Transfer Embryos

24 Jun 2014

Abstract excerpt

Low cloning efficiency is considered to be caused by the incomplete or aberrant epigenetic reprogramming of differentiated donor cells in somatic cell nuclear transfer (SCNT) embryos. Oxamflatin, a novel class of histone deacetylase inhibitor (HDACi), has been found to improve the in vitro and full-term developmental potential of SCNT embryos. In the present study, we studied the effects of oxamflatin treatment...

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PMID: 24960409
DOI: 10.1089/cell.2013.0058

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Effects of Histone Deacetylase Inhibitor Oxamflatin on <i>In Vitro</i> Porcine Somatic Cell Nuclear Transfer EmbryosPMID 24960409Read ↗

Oxamflatin Improves Developmental Competence of Porcine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Oxamflatin Treatment Enhances Cloned Porcine Embryo Development and Nuclear Reprogramming <sup/>Semantic proximity Read ↗

Oxamflatin Significantly Improves Nuclear Reprogramming, Blastocyst Quality, and In Vitro Development of Bovine SCNT EmbryosSemantic proximity Read ↗

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MC1568 Enhances Histone Acetylation During Oocyte Meiosis and Improves Development of Somatic Cell Nuclear Transfer Embryos in PigSemantic proximity Read ↗

Histone Deacetylase Inhibitor Significantly Improved the Cloning Efficiency of Porcine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

The HDAC Inhibitor LAQ824 Enhances Epigenetic Reprogramming and In Vitro Development of Porcine SCNT EmbryosSemantic proximity Read ↗

Histone Deacetylase Inhibitors Improve <i>In Vitro</i> and <i>In Vivo</i> Developmental Competence of Somatic Cell Nuclear Transfer Porcine EmbryosSemantic proximity Read ↗

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