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MicroRNA-148a overexpression improves the early development of porcine somatic cell nuclear transfer embryos

30 Jun 2017

Abstract excerpt

Incomplete epigenetic reprogramming of donor cell nuclei is one of the main contributors to the low efficiency of somatic cell nuclear transfer (SCNT). To improve the success of SCNT, somatic cell DNA methylation levels must be reduced to those levels found in totipotent embryonic cells. Recent studies have demonstrated that miR-148a can affect DNA methylation via DNMT1 modulation in various cancers. Therefore,...

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PMID: 28665977
DOI: 10.1371/journal.pone.0180535

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