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Article

Aberrant DNA and histone methylation during zygotic genome activation in goat cloned embryos.

Theriogenology - 1 May 2020

Deng Mingtian, Liu Zifei, Chen Baobao, Wan Yongjie, Yang Hua, Zhang Yanli, Cai Yu, Zhou Jianguo, Wang Feng

Abstract excerpt

In somatic cell nuclear transfer (SCNT) embryos, developmental defects first appear at the time of zygotic genome activation (ZGA), a process that is under the control of DNA and histone methylation. However, dynamics of 5-mC and 5-hmC during ZGA differ between porcine and bovine SCNT embryos, and histone methylation during ZGA in goat SCNT embryos remains poorly understood. Therefore, in the present study, we...

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Identifiers

PMID: 32126393
DOI: 10.1016/j.theriogenology.2020.02.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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