Article
Genetic Determinants of Lipids and Cardiovascular Disease Outcomes: A Wide-Angled Mendelian Randomization Investigation.
Circulation. Genomic and precision medicine - 1 Dec 2019
Allara Elias, Morani Gabriele, Carter Paul, Gkatzionis Apostolos, Zuber Verena, Foley Christopher N, Rees Jessica M B, Mason Amy M, Bell Steven, Gill Dipender, Lindström Sara, Butterworth Adam S, Di Angelantonio Emanuele, Peters James, Burgess Stephen
Abstract excerpt
BACKGROUND: Evidence from randomized trials has shown that therapies that lower LDL (low-density lipoprotein)-cholesterol and triglycerides reduce coronary artery disease (CAD) risk. However, there is still uncertainty about their effects on other cardiovascular outcomes. We therefore performed a systematic investigation of causal relationships between circulating lipids and cardiovascular outcomes using a...
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