Article
An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
Anticancer research - 1 Jul 2017
Nishi Kensuke, Luo Hao, Nakabayashi Kazuhiko, Doi Keiko, Ishikura Shuhei, Iwaihara Yuri, Yoshida Yasuhiro, Tanisawa Kumpei, Arai Tomio, Mori Seijiro, Sawabe Motoji, Muramatsu Masaaki, Tanaka Masashi, Sakata Toshifumi, Shirasawa Senji, Tsunoda Toshiyuki
Abstract excerpt
BACKGROUND/AIM: Alpha-kinase 2 (ALPK2), suggested to be a novel tumour-suppressor gene down-regulated by oncogenic KRAS, plays a pivotal role in luminal apoptosis in normal colonic crypts. The aim of this study was to determine the association between ALPK2 germline variants and colorectal cancer. MATERIALS AND METHODS: Missense single nucleotide variants in the exons of the ALPK2 gene in 2,343 consecutive...
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