Article

p20BAP31 induces cell apoptosis via both ROS/JNK mitochondrial pathway and AIF caspase-independent pathway

2022-08-16

Abstract excerpt

<h4>Background: </h4> B-cell receptor associated protein 31 (BAP31) is a polytopic integral endoplasmic reticulum (ER) membrane protein. During cell apoptosis, the c-terminal of BAP31 was cleaved by caspase-8, generates the residual 20kDa proteolytic fragment (p20BAP31), which not only induces cell apoptosis, but also initiates a paraptosis-like cell death pathway when expressed ectopically. This property of induc...

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Literature Corpus work: 3a17ea29-6894-506f-af11-d77c70694abc
DOI: 10.21203/rs.3.rs-1949131/v1

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