Article
The role of metabolic reprogramming of oxygen-induced macrophages in the dynamic changes of atherosclerotic plaques.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2023
Shen Lin, Chen Weiyue, Ding Jiayi, Shu Gaofeng, Chen Minjiang, Zhao Zhongwei, Xia Shuiwei, Ji Jiansong
Abstract excerpt
Atherosclerosis (As) is a chronic vascular inflammatory disease. Macrophages are the most important immune cells in atherosclerotic plaques, and the phenotype of plaque macrophages shifts dynamically to adapt to changes in the plaque microenvironment. The aerobic microenvironment of early atherosclerotic plaques promotes the transformation of M2/alternatively activated macrophages mainly through oxidative...
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