Article
A channelopathy mechanism revealed by direct calmodulin activation of TrpV4.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015
Loukin Stephen H, Teng Jinfeng, Kung Ching
Abstract excerpt
Ca(2+)-calmodulin (CaM) regulates varieties of ion channels, including Transient Receptor Potential vanilloid subtype 4 (TrpV4). It has previously been proposed that internal Ca(2+) increases TrpV4 activity through Ca(2+)-CaM binding to a C-terminal Ca(2+)-CaM binding domain (CBD). We confirmed this model by directly presenting Ca(2+)-CaM protein to membrane patches excised from TrpV4-expressing oocytes. Over 50...
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