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Article

Forward genetic analysis reveals multiple gating mechanisms of TRPV4.

The Journal of biological chemistry - 25 Jun 2010

Loukin Stephen, Su Zhenwei, Zhou Xinliang, Kung Ching

Abstract excerpt

TRPV4 is a polymodal cation channel gain-of-function (GOF) allele which causes skeletal dysplasia in humans. To better understand its gating, we screened for additional GOF alleles based on their ability to block yeast proliferation. Repeatedly, only a limited number of such growth-blocking mutat...

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Identifiers

PMID: 20424166
DOI: 10.1074/jbc.M110.113936
PMCID: PMC2888399

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20424166-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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