The <scp>l,d</scp>-Transpeptidase Ldt_Ab from <i>Acinetobacter baumannii</i> Is Poorly Inhibited by Carbapenems and Has a Unique Structural Architecture

Abstract excerpt

l,d -Transpeptidases (LDTs) are enzymes that catalyze reactions essential for biogenesis of the bacterial cell wall, including formation of 3–3 cross-linked peptidoglycan. Unlike the historically well-known bacterial transpeptidases, the penicillin-binding proteins (PBPs), LDTs are resistant to inhibition by the majority of β-lactam antibiotics, with the exception of carbapenems and penems, allowing bacteria to...

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