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Article

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.

Nature communications - 19 Feb 2015

Gersch Malte, Famulla Kirsten, Dahmen Maria, Göbl Christoph, Malik Imran, Richter Klaus, Korotkov Vadim S, Sass Peter, Rübsamen-Schaeff Helga, Madl Tobias, Brötz-Oesterhelt Heike, Sieber Stephan A

Abstract excerpt

The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here we show that both protein and small-molecule activators of ClpP allosterically control the ClpP...

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PMID: 25695750
DOI: 10.1038/ncomms7320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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