Article
Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure.
ACS chemical biology - 15 Jul 2016
Ni Tengfeng, Ye Fei, Liu Xing, Zhang Jie, Liu Hongchuan, Li Jiahui, Zhang Yingyi, Sun Yinqiang, Wang Meining, Luo Cheng, Jiang Hualiang, Lan Lefu, Gan Jianhua, Zhang Ao, Zhou Hu, Yang Cai-Guang
Abstract excerpt
ATP-dependent Clp protease (ClpP), a highly conserved serine protease in vast bacteria, could be converted into a noncontrollable enzyme capable of degrading mature proteins in the presence of acyldepsipeptides (ADEPs). Here, we design such a gain-of-function mutant of Staphylococcus aureus ClpP (SaClpP) capable of triggering the same level of dysfunctional activity that occurs upon ADEPs treatment. The...
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