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Article

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease

11 Jun 2014

Abstract excerpt

The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/CXCR4 interaction has long been regarded as a monogamous relation, the identification of the pro-inflammatory chemokine macrophage migration inhibitory factor...

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PMID: 24966838
DOI: 10.3389/fphys.2014.00212

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