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Article

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.

Nature communications - 13 Mar 2020

Kwak Sang Su, Washicosky Kevin J, Brand Emma, von Maydell Djuna, Aronson Jenna, Kim Susan, Capen Diane E, Cetinbas Murat, Sadreyev Ruslan, Ning Shen, Bylykbashi Enjana, Xia Weiming, Wagner Steven L, Choi Se Hoon, Tanzi Rudolph E, Kim Doo Yeon

Abstract excerpt

The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer's disease (AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ level, plays a critical role in inducing neurofibrillary tangles (NTFs) in human neurons. Using 3D-differentiated clonal human neural progenitor cells (hNPCs) expressing varying levels of amyloid β precursor protein (APP) and...

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Identifiers

PMID: 32170138
DOI: 10.1038/s41467-020-15120-3
PMCID: PMC7070004

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