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Article

A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.

The American journal of pathology - 1 Oct 2010

Hurtado David E, Molina-Porcel Laura, Iba Michiyo, Aboagye Awo K, Paul Steven M, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Senile plaques formed by β-amyloid peptides (Aβ) and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau, a microtubule-associated protein, are the hallmark lesions of Alzheimer's disease (AD) in addition to loss of neurons. While several transgenic (Tg) mouse models have recapitulated aspects of AD-like Aβ and tau pathologies, a spatiotemporal mapping paradigm for progressive NFT accumulation is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20802182
DOI: 10.2353/ajpath.2010.100346
PMCID: PMC2947292

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