Article
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Neuron - 1 Nov 1996
Borchelt D R, Thinakaran G, Eckman C B, Lee M K, Davenport F, Ratovitsky T, Prada C M, Kim G, Seekins S, Yager D, Slunt H H, Wang R, Seeger M, Levey A I, Gandy S E, Copeland N G, Jenkins N A, Price D L, Younkin S G, Sisodia S S
Abstract excerpt
Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Abeta1-42(43)/Abeta1-40 ratio in the conditioned media of independent N2a cell lines expressing three FAD-linked PS1 variants is uniformly elevated relative to cells expressing similar levels of wild-type PS1. Similarly, the...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Brain Chemistry
- Culture Media, Conditioned
- Gene Expression
- Humans
- Membrane Proteins
- Mice
- Mice, Transgenic