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Article

Characterization of a Mouse Model of Alzheimer's Disease Expressing Aβ4-42 and Human Mutant Tau.

International journal of molecular sciences - 14 May 2021

Zampar Silvia, Wirths Oliver

Abstract excerpt

The relationship between the two most prominent neuropathological hallmarks of Alzheimer's Disease (AD), extracellular amyloid-β (Aβ) deposits and intracellular accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFT), remains at present not fully understood. A large body of evidence places Aβ upstream in the cascade of pathological events, triggering NFTs formation and the subsequent neuron loss....

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Identifiers

PMID: 34069029
DOI: 10.3390/ijms22105191
PMCID: PMC8156793

Genes

CA1

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