Article
A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets.
Human molecular genetics - 15 Dec 2010
Phipps-Green Amanda J, Hollis-Moffatt Jade E, Dalbeth Nicola, Merriman Marilyn E, Topless Ruth, Gow Peter J, Harrison Andrew A, Highton John, Jones Peter B B, Stamp Lisa K, Merriman Tony R
Abstract excerpt
Genetic variation in ABCG2 (rs2231142, Q141K), encoding a uric acid transporter, is associated with gout in diverse populations. The aim of this study was to examine a role for ABCG2 in gout susceptibility in New Zealand Māori, Pacific Island and Caucasian samples. Patients (n = 185, 173 and 214, for Māori, Pacific Island and Caucasian, respectively) satisfied the American College of Rheumatology gout...
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