Article
Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2017
Tanner Callum, Boocock James, Stahl Eli A, Dobbyn Amanda, Mandal Asim K, Cadzow Murray, Phipps-Green Amanda J, Topless Ruth K, Hindmarsh Jennie Harré, Stamp Lisa K, Dalbeth Nicola, Choi Hyon K, Mount David B, Merriman Tony R
Abstract excerpt
OBJECTIVE: There is no evidence for a genetic association between organic anion transporters 1-3 (SLC22A6, SLC22A7, and SLC22A8) and multidrug resistance protein 4 (MRP4; encoded by ABCC4) with the levels of serum urate or gout. The Māori and Pacific (Polynesian) population of New Zealand has the highest prevalence of gout worldwide. The aim of this study was to determine whether any Polynesian...
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