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Article

Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout.

Hereditas - 27 Jan 2020

Dong Zheng, Zhou Jingru, Jiang Shuai, Li Yuan, Zhao Dongbao, Yang Chengde, Ma Yanyun, He Hongjun, Ji Hengdong, Jin Li, Zou Hejian, Wang Jiucun

Abstract excerpt

BACKGROUND: Genetic background affects serum urate concentration and gout risk, especially regarding these variants in the urate-transporter gene ABCG2. However, the role of epistasis between PKD2 and ABCG2 on the pathogenesis of gout is poorly understood. Here we assess this epistatic interaction in the progression from elevated serum urate to gout. RESULTS: We identified two epistatic interaction pairs...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Hyperuricemia

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Share to TRPP Cation Channels

Share to Uric Acid

Source

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Identifiers

PMID: 32000861
DOI: 10.1186/s41065-020-0116-6
PMCID: PMC6986014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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