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Article

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease.

The Journal of clinical investigation - 2 Feb 2026

Sezaki Maiko, Li Tian, Pan Mingzhe, Wang Zhihong, Bai Jie, Horowitz Justin G, Xu Julia Z, Huang Gang

Abstract excerpt

Preclinical data demonstrating that luspatercept mitigates vaso-occlusive and anemia-related complications in the Townes sickle cell model provide a strong rationale for its evaluation in SCD patients.

Read the complete abstract on PubMed

Topics

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Share to Activin Receptors, Type II
Share to Anemia, Sickle Cell
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41623180
DOI: 10.1172/JCI197706
PMCID: PMC12867147

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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