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Article

Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency

26 Mar 2017

Abstract excerpt

Diseases caused by gene haploinsufficiency in humans commonly lack a phenotype in mice that are heterozygous for the orthologous factor, impeding the study of complex phenotypes and critically limiting the discovery of therapeutics. Laboratory mice have longer telomeres relative to humans, potentially protecting against age-related disease caused by haploinsufficiency. Here, we demonstrate that telomere...

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PMID: 28346225
DOI: 10.1172/jci90338

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