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Article

Impaired Collateral Vessel Formation in Sickle Cell Disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2018

Okwan-Duodu Derick, Hansen Laura, Joseph Giji, Lyle Alicia N, Weiss Daiana, Archer David R, Taylor W Robert

Abstract excerpt

OBJECTIVE: The adaptive response to vascular injury is the formation of functional collateral vessels to maintain organ integrity. Many of the clinical complications associated with sickle cell disease can be attributed to repeated bouts of vascular insufficiency, yet the detailed mechanisms of collateral vessel formation after injury are largely unknown in sickle cell disease. Here, we characterize postischemic...

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Identifiers

PMID: 29545241
DOI: 10.1161/ATVBAHA.118.310771
PMCID: PMC5920704

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