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Article

Mineralocorticoid Excess or Glucocorticoid Insufficiency: Renal and Metabolic Phenotypes in a Rat Hsd11b2 Knockout Model.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2015

Mullins Linda J, Kenyon Christopher J, Bailey Matthew A, Conway Bryan R, Diaz Mary E, Mullins John J

Abstract excerpt

Obesity and hypertension are 2 major health issues of the 21st century. The syndrome of apparent mineralocorticoid excess is caused by deficiency of 11β-hydroxysteroid dehydrogenase type 2 (Hsd11b2), which normally inactivates glucocorticoids, rendering the mineralocorticoid receptor aldosterone-specific. The metabolic consequences of Hsd11b2 knockout in the rat are investigated in parallel with electrolyte...

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Identifiers

PMID: 26077568
DOI: 10.1161/HYPERTENSIONAHA.115.05262
PMCID: PMC4847935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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