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Article

Practical adoption of state-of-the-art hiPSC-cardiomyocyte differentiation techniques.

PloS one - 1 Jan 2020

Rupert Cassady E, Irofuala Chinedu, Coulombe Kareen L K

Abstract excerpt

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes are a valuable resource for cardiac therapeutic development; however, generation of these cells in large numbers and high purity is a limitation in widespread adoption. Here, design of experiments (DOE) is used to investigate the cardiac differentiation space of three hiPSC lines when varying CHIR99027 concentration and cell seeding density, and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32155214
DOI: 10.1371/journal.pone.0230001
PMCID: PMC7064240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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