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Article

Cauchy combination methods for the detection of gene-environment interactions for rare variants related to quantitative phenotypes.

Heredity - 1 Oct 2023

Jin Xiaoqin, Shi Gang

Abstract excerpt

The characterization of gene-environment interactions (GEIs) can provide detailed insights into the biological mechanisms underlying complex diseases. Despite recent interest in GEIs for rare variants, published GEI tests are underpowered for an extremely small proportion of causal rare variants in a gene or a region. By extending the aggregated Cauchy association test (ACAT), we propose three GEI tests to...

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Identifiers

PMID: 37481617
DOI: 10.1038/s41437-023-00640-7
PMCID: PMC10539363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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