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Article

Evolutionary repair: Changes in multiple functional modules allow meiotic cohesin to support mitosis.

PLoS biology - 1 Mar 2020

Hsieh Yu-Ying Phoebe, Makrantoni Vasso, Robertson Daniel, Marston Adèle L, Murray Andrew W

Abstract excerpt

The role of proteins often changes during evolution, but we do not know how cells adapt when a protein is asked to participate in a different biological function. We forced the budding yeast, Saccharomyces cerevisiae, to use the meiosis-specific kleisin, recombination 8 (Rec8), during the mitotic cell cycle, instead of its paralog, Scc1. This perturbation impairs sister chromosome linkage, advances the timing of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32155147
DOI: 10.1371/journal.pbio.3000635
PMCID: PMC7138332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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