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Article

Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.

PLoS genetics - 1 Nov 2021

Fumasoni Marco, Murray Andrew W

Abstract excerpt

In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories depend on genomic features by comparing the adaptation in three strains: haploids, diploids, and recombination deficient haploids. In all three, adaptation happens within 1000...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34752451
DOI: 10.1371/journal.pgen.1009875
PMCID: PMC8604288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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