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Article

A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase.

Disease models & mechanisms - 1 Aug 2015

Holmbeck Marissa A, Donner Julia R, Villa-Cuesta Eugenia, Rand David M

Abstract excerpt

Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes, which produce the majority of cellular energy, requires the coordinated expression and translation of both mitochondrially and nuclear-encoded proteins. The joint genetic architecture of this system complicates the basis of mitochondrial diseases, and mutations both in...

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Identifiers

PMID: 26035388
DOI: 10.1242/dmm.019323
PMCID: PMC4527286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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