Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial genotype alters the impact of rapamycin on the transcriptional response to nutrients in Drosophila.

BMC genomics - 24 Mar 2021

Santiago John C, Boylan Joan M, Lemieux Faye A, Gruppuso Philip A, Sanders Jennifer A, Rand David M

Abstract excerpt

BACKGROUND: In addition to their well characterized role in cellular energy production, new evidence has revealed the involvement of mitochondria in diverse signaling pathways that regulate a broad array of cellular functions. The mitochondrial genome (mtDNA) encodes essential components of the oxidative phosphorylation (OXPHOS) pathway whose expression must be coordinated with the components transcribed from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Mitochondria

Share to Nutrients

Share to Sirolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 33761878
DOI: 10.1186/s12864-021-07516-2
PMCID: PMC7992956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial genotype alters the impact of rapamycin on the transcriptional response to nutrients in Drosophila.PMID 33761878Read ↗

Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes.Semantic proximity Read ↗

Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila.Semantic proximity Read ↗

Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila.Semantic proximity Read ↗

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel.Semantic proximity Read ↗

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitnessSemantic proximity Read ↗

G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity.Semantic proximity Read ↗

Mitochondrial Dysfunction and Infection Generate Immunity-Fecundity Tradeoffs in Drosophila.Semantic proximity Read ↗

Rapamycin enhances survival in a Drosophila model of mitochondrial disease.Semantic proximity Read ↗

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.Semantic proximity Read ↗

Treatment with mitochondrial targeting antibiotics improves survival outcomes after Flock House virus infection in young and aged Drosophila melanogasterSemantic proximity Read ↗

Yin and Yang of mitochondrial ROS in Drosophila.Semantic proximity Read ↗

Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.