Article
CDH1 gene mutation in early-onset, colorectal signet-ring cell carcinoma.
Pathology, research and practice - 1 May 2020
Aitchison Alan, Hakkaart Christopher, Whitehead Martin, Khan Sadaf, Siddique Sabeehuddin, Ahmed Rashida, Frizelle Frank A, Keenan Jacqueline I
Abstract excerpt
AIM: Colorectal signet-ring cell carcinomas (SRCC) are highly malignant tumours with poor prognosis that disproportionately affect younger patients. There is growing evidence of a unique set of molecular features that separate SRCC from conventional colorectal adenocarcinoma. Identification of these distinct features may have diagnostic and prognostic significance for patients and families. CDH1, which encodes...
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