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Article

A common variant in PNPLA3 is associated with age at diagnosis of NAFLD in patients from a multi-ethnic biobank.

Journal of hepatology - 1 Jun 2020

Walker Ryan W, Belbin Gillian M, Sorokin Elena P, Van Vleck Tielman, Wojcik Genevieve L, Moscati Arden, Gignoux Christopher R, Cho Judy, Abul-Husn Noura S, Nadkarni Girish, Kenny Eimear E, Loos Ruth J F

Abstract excerpt

BACKGROUND & AIMS: The Ile138Met variant (rs738409) in the PNPLA3 gene has the largest effect on non-alcoholic fatty liver disease (NAFLD), increasing the risk of progression to severe forms of liver disease. It remains unknown if the variant plays a role in age of NAFLD onset. We aimed to determine if rs738409 impacts on the age of NAFLD diagnosis. METHODS: We applied a novel natural language processing (NLP)...

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Identifiers

PMID: 32145261
DOI: 10.1016/j.jhep.2020.01.029
PMCID: PMC7840172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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