PNPLA3 rs738409, age, diabetes, sex, and advanced fibrosis jointly contribute to the risk of major adverse liver outcomes in metabolic dysfunction-associated steatotic liver disease.

doi:10.1097/HEP.0000000000000896

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PNPLA3 rs738409, age, diabetes, sex, and advanced fibrosis jointly contribute to the risk of major adverse liver outcomes in metabolic dysfunction-associated steatotic liver disease.

Hepatology (Baltimore, Md.) - 1 Nov 2024

Chalasani Naga, Vilar-Gomez Eduardo, Loomba Rohit, Yates Katherine P, Diehl Anna Mae, Neuschwander-Tetri Brent A, Dasarathy Srinivasan, Kowdley Kris V, Terrault Norah, Wilson Laura A, Tonascia James, Sanyal Arun J

Abstract excerpt

BACKGROUND AND AIMS: The patatin-like phospholipase domain-containing protein 3 ( PNPLA3 ) rs738409 variant is associated with steatotic liver disease and its progression. We examined the association between PNPLA3 and the development of major adverse liver outcomes (MALOs) and how nonmodifiable and modifiable conditions modify this relationship. APPROACH AND RESULTS: A total of 2075 adults with biopsy-confirmed...

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PMID: 38652636
DOI: 10.1097/HEP.0000000000000896
PMCID: PMC11798878

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PNPLA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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