Article
The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain.
Communications biology - 5 Mar 2020
Nakamura Seiko, Matsui Aiko, Akabane Shiori, Tamura Yasushi, Hatano Azumi, Miyano Yuriko, Omote Hiroshi, Kajikawa Mizuho, Maenaka Katsumi, Moriyama Yoshinori, Endo Toshiya, Oka Toshihiko
Abstract excerpt
LETM1 is a mitochondrial inner membrane protein that is required for maintaining the mitochondrial morphology and cristae structures, and regulates mitochondrial ion homeostasis. Here we report a role of LETM1 in the organization of cristae structures. We identified four amino acid residues of human LETM1 that are crucial for complementation of the growth deficiency caused by gene deletion of a yeast LETM1...
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