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Article

Trypanosome Letm1 protein is essential for mitochondrial potassium homeostasis.

The Journal of biological chemistry - 13 Sept 2013

Hashimi Hassan, McDonald Lindsay, Stríbrná Eva, Lukeš Julius

Abstract excerpt

Letm1 is a conserved protein in eukaryotes bearing energized mitochondria. Hemizygous deletion of its gene has been implicated in symptoms of the human disease Wolf-Hirschhorn syndrome. Studies almost exclusively performed in opisthokonts have attributed several roles to Letm1, including maintaining mitochondrial morphology, mediating either calcium or potassium/proton antiport, and facilitating mitochondrial...

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Identifiers

PMID: 23893410
DOI: 10.1074/jbc.M113.495119
PMCID: PMC3772241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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