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Article

The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome.

The Journal of biological chemistry - 16 Jul 2004

Nowikovsky Karin, Froschauer Elisabeth M, Zsurka Gabor, Samaj Jozef, Reipert Siegfried, Kolisek Martin, Wiesenberger Gerlinde, Schweyen Rudolf J

Abstract excerpt

The yeast open reading frames YOL027 and YPR125 and their orthologs in various eukaryotes encode proteins with a single predicted trans-membrane domain ranging in molecular mass from 45 to 85 kDa. Hemizygous deletion of their human homolog LETM1 is likely to contribute to the Wolf-Hirschhorn syndrome phenotype. We show here that in yeast and human cells, these genes encode integral proteins of the inner...

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Source

Identifiers

PMID: 15138253
DOI: 10.1074/jbc.M403607200

Genes

LETM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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