Article
Inverse correlation between expression of the Wolfs Hirschhorn candidate gene Letm1 and mitochondrial volume in C. elegans and in mammalian cells.
Human molecular genetics - 1 Sept 2007
Hasegawa Ayako, van der Bliek Alexander M
Abstract excerpt
Deletion of the Letm1 gene correlates with the occurrence of epilepsy in patients with Wolf-Hirschhorn syndrome. The Letm1 gene encodes a mitochondrial protein that is homologous to yeast Mdm38. Yeast Mdm38 is localized to the mitochondrial inner membrane where it was proposed to act as a K+/H+ antiporter or alternatively as a chaperone for selected mitochondrial inner membrane proteins. Here, we present cellular...
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