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Article

Frequent alteration of the tumor suppressor gene APC in sporadic canine colorectal tumors.

PloS one - 1 Jan 2012

Youmans Lydia, Taylor Cynthia, Shin Edwin, Harrell Adrienne, Ellis Angela E, Séguin Bernard, Ji Xinglai, Zhao Shaying

Abstract excerpt

Sporadic canine colorectal cancers (CRCs) should make excellent models for studying the corresponding human cancers. To molecularly characterize canine CRC, we investigated exonic sequence mutations of adenomatous polyposis coli (APC), the best known tumor suppressor gene of human CRC, in 23 sporadic canine colorectal tumors, including 8 adenomas and 15 adenocarcinomas, via exon-resequencing analysis. As a...

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Identifiers

PMID: 23251390
DOI: 10.1371/journal.pone.0050813
PMCID: PMC3519478

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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