Article
DMSO-mediated curing of several yeast prion variants involves Hsp104 expression and protein solubilization, and is decreased in several autophagy related gene (atg) mutants.
PloS one - 1 Jan 2020
Dorweiler Jane E, Obaoye Joanna O, Oddo Mitch J, Shilati Francesca M, Scheidemantle Grace M, Coleman Thomas J, Reilly Jacob A, Smith Gregory R, Manogaran Anita L
Abstract excerpt
Chaperones and autophagy are components of the protein quality control system that contribute to the management of proteins that are misfolded and aggregated. Here, we use yeast prions, which are self-perpetuating aggregating proteins, as a means to understand how these protein quality control systems influence aggregate loss. Chaperones, such as Hsp104, fragment prion aggregates to generate more prion seeds for...
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