Article
Distinct amino acid compositional requirements for formation and maintenance of the [PSI⁺] prion in yeast.
Molecular and cellular biology - 1 Mar 2015
MacLea Kyle S, Paul Kacy R, Ben-Musa Zobaida, Waechter Aubrey, Shattuck Jenifer E, Gruca Margaret, Ross Eric D
Abstract excerpt
Multiple yeast prions have been identified that result from the structural conversion of proteins into a self-propagating amyloid form. Amyloid-based prion activity in yeast requires a series of discrete steps. First, the prion protein must form an amyloid nucleus that can recruit and structurally convert additional soluble proteins. Subsequently, maintenance of the prion during cell division requires...
Topics
- Amino Acid Sequence
- Amino Acids
- Amyloid
- Gene Library
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Peptide Termination Factors
- Prions
- Protein Denaturation
- Protein Folding