Article
Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective.
Nucleic acids research - 17 Apr 2020
Pande Amit, Makalowski Wojciech, Brosius Jürgen, Raabe Carsten A
Abstract excerpt
Analysis of ENCODE long RNA-Seq and ChIP-seq (Chromatin Immunoprecipitation Sequencing) datasets for HepG2 and HeLa cell lines uncovered 1647 and 1958 transcripts that interfere with transcription factor binding to human enhancer domains. TFBSs (Transcription Factor Binding Sites) intersected by these 'Enhancer Occlusion Transcripts' (EOTrs) displayed significantly lower relative transcription factor (TF) binding...
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