Article
Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt.
BMC bioinformatics - 3 Mar 2020
Romijn Lotte B, Almet Axel A, Tan Chin Wee, Osborne James M
Abstract excerpt
BACKGROUND: Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting in cancer. Previous work has proposed how cell level properties can lead to mutant cell invasion, but has not incorporated detailed subcellular modelling RESULTS: We present a framework that allows the straightforward...
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