Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt.

Journal of theoretical biology - 7 Nov 2012

Mirams Gary R, Fletcher Alexander G, Maini Philip K, Byrne Helen M

Abstract excerpt

The surface epithelium lining the intestinal tract renews itself rapidly by a coordinated programme of cell proliferation, migration and differentiation events that is initiated in the crypts of Lieberkühn. It is generally believed that colorectal cancer arises due to mutations that disrupt the n...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Cell Adhesion
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to Computer Simulation

Share to Epithelial Cells

Share to Intestinal Mucosa

Source

Identifiers

PMID: 22902425
DOI: 10.1016/j.jtbi.2012.08.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22902425-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt.PMID 22902425Read ↗

Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts.Semantic proximity Read ↗

Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesisSemantic proximity Read ↗

Immune Control of Oncogene Selection in the Colon.Semantic proximity Read ↗

Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesis.Semantic proximity Read ↗

Multi-scale modeling of APC and [Formula: see text]-catenin regulation in the human colonic crypt.Semantic proximity Read ↗

The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts.Semantic proximity Read ↗

A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesisSemantic proximity Read ↗

Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.Semantic proximity Read ↗

Modeling of stem cell dynamics in human colonic crypts in silico.Semantic proximity Read ↗

Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer.Semantic proximity Read ↗

A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments.Semantic proximity Read ↗

The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.