The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt.

doi:10.1007/s11538-025-01588-x

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Article

The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt.

Bulletin of mathematical biology - 9 Feb 2026

Atkinson George, Leedham Simon, Byrne Helen M

Abstract excerpt

Intestinal crypts are test tube-like structures lined with an epithelial monolayer. Under homeostasis, mitotic forces drive epithelial cells to migrate up the crypt, from the stem cell niche. As the cells migrate up the crypt, they differentiate into specialised cells. This process is regulated by morphogen gradients established by distinct populations of subepithelial fibroblasts, and recent studies suggest...

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PMID: 41656447
DOI: 10.1007/s11538-025-01588-x
PMCID: PMC12883536

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