Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modularity/non-cumulativity of quantitative trait loci on blood pressure.

Journal of human hypertension - 1 Jun 2020

Deng Alan Y

Abstract excerpt

Large numbers of quantitative trait loci (QTLs) for blood pressure (BP) exist and have long been thought to function by accumulating their individual miniscule effects. Recent experimental evidence in the functional biology of BP control has tested this intuitive assumption. A new paradigm has emerged that BP is biologically determined in modularity by multiple QTLs. Functionally, when a master regulator is taken...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Epistasis, Genetic
Share to Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Rats, Inbred Dahl

Source

Identifiers

PMID: 32123286
DOI: 10.1038/s41371-020-0319-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modularity/non-cumulativity of quantitative trait loci on blood pressure.PMID 32123286Read ↗

Genetic mechanisms of polygenic hypertension: fundamental insights from experimental models.Semantic proximity Read ↗

Conserved mammalian modularity of quantitative trait loci revealed human functional orthologs in blood pressure control.Semantic proximity Read ↗

Genetic basis of polygenic hypertensionSemantic proximity Read ↗

Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Semantic proximity Read ↗

Integrative network analysis reveals molecular mechanisms of blood pressure regulation.Semantic proximity Read ↗

Genetically complex cardiovascular traits. Origins, problems, and potential solutions.Semantic proximity Read ↗

From genetics to mechanism of disease liability.Semantic proximity Read ↗

Extensions to quantitative trait locus mapping in experimental organisms.Semantic proximity Read ↗

Genetics of essential hypertension: from families to genes.Semantic proximity Read ↗

Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension.Semantic proximity Read ↗

Functional Captures of Multiple Human Quantitative Trait Loci Regulating Blood Pressure with the Use of Orthologs in Genetically Defined Rat Models.Semantic proximity Read ↗

Epistatic study reveals two genetic interactions in blood pressure regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.