Article
Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Molecular systems biology - 16 Apr 2015
Huan Tianxiao, Meng Qingying, Saleh Mohamed A, Norlander Allison E, Joehanes Roby, Zhu Jun, Chen Brian H, Zhang Bin, Johnson Andrew D, Ying Saixia, Courchesne Paul, Raghavachari Nalini, Wang Richard, Liu Poching, O'Donnell Christopher J, Vasan Ramachandran, Munson Peter J, Madhur Meena S, Harrison David G, Yang Xia, Levy Daniel
Abstract excerpt
Genome-wide association studies (GWAS) have identified numerous loci associated with blood pressure (BP). The molecular mechanisms underlying BP regulation, however, remain unclear. We investigated BP-associated molecular mechanisms by integrating BP GWAS with whole blood mRNA expression profiles in 3,679 individuals, using network approaches. BP transcriptomic signatures at the single-gene and the coexpression...
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