Article
Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.
Current hypertension reports - 1 Feb 2012
Basson Jacob, Simino Jeannette, Rao D C
Abstract excerpt
Blood pressure has a significant genetic component, but less than 3% of the observed variance has been attributed to genetic variants identified to date. Candidate gene studies of rare, monogenic hypertensive syndromes have conclusively implicated several genes altering renal sodium balance, and studies of essential hypertension have inconsistently implicated over 50 genes in pathways affecting renal sodium...
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