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Neurexins in autism and schizophrenia-a review of patient mutations, mouse models and potential future directions.

Molecular psychiatry - 1 Mar 2021

Tromp Alisha, Mowry Bryan, Giacomotto Jean

Abstract excerpt

Mutations in the family of neurexins (NRXN1, NRXN2 and NRXN3) have been repeatedly identified in patients with autism spectrum disorder (ASD) and schizophrenia (SCZ). However, it remains unclear how these DNA variants affect neurexin functions and thereby predispose to these neurodevelopmental disorders. Understanding both the wild-type and pathologic roles of these genes in the brain could help unveil biological...

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Identifiers

PMID: 33191396
DOI: 10.1038/s41380-020-00944-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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